Diuretic activity of 3-N-butylamino-4-phenoxy-5-sulphamyl benzoic acid (bumetanide) in hamster.

Bumetanide is a 3-aminobenzoic acid derivative. Of the several analogues having various substituents which are about equally active in test animals (3). Ostergaard elal. (5) selected 3-n-butylamino-4-phenoxy·5-sulphamyl benzoic acid (bumetanide) and studied its pharmacological properties. including its diuretic action in rats and dogs. Besides the diuretic effect bumetanide displayed hardly any significant pharmamacological activity. It is almost inactive in rat. except at extremely high doses. In the dog. it is about 100 times more active when given orally. In the present study, its diuretic activity in hamster is described. It is a potent diuretic after olal administration in hamster. Its type of action is comparable with furosemide but it is nearly 40 to 80 times more active than furosemide in relation to excretion of water and sodium respectively.